Research

We are interested in the mechanisms leading to Alzheimer's disease, with a special emphasis on the role of APOE and glial cells.

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Team

Led by Dr. Alberto Serrano-Pozo, we are an interdisciplinary team dedicated to ensuring a brighter future for patients with neurodegenerative diseases.

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Location

We are located in Charlestown, MA within the MassGeneral Institute for Neurodegenerative Disease (MIND) at Massachusetts General Hospital and Harvard Medical School.

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Featured Work

Please see some of the most recent publications and projects from our group below.

Astrocyte Atlas

A public database of astrocyte immunohistochemical studies in postmortem Alzheimer's disease brains.

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Consensus Statement

Recently published in Nature Neuroscience, this consensus statement advocates for increased nuance in reactive astrocyte classification.

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APOE and Alzheimer's

This review, published in The Lancet Neurology, charts the progress in the effort to design APOE-based therapies for Alzheimer's disease.

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Context Dependent Reaction

Published in the Journal of Neuroinflammation, this meta-analysis of mouse transcriptomics indicates that astrocyte reaction is context-dependent.

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